EIC Transition Grant "OptoWavePro"

About the project

OptoWavePro develops a human prototype for an optical stimulator for optogenetic hearing restoration in individuals with profound hearing impairment. Leveraging optogenetics and biomedical engineering, we strive to restore near-natural hearing by precise optogenetic control of the auditory nerve for which we obtained preclinical proof. Our multidisciplinary team designs, fabricates, and validates the optical stimulator, emphasizing safety, efficacy, and regulatory compliance. Preclinical studies validate efficacy, reliability, and biocompatibility, to prepare clinical trials.

The OptoWavePro consortium introduces a new paradigm of integrating arrays of laser diodes, micro-lenses and polymer-based waveguides on minimal space for the optical stimulator to meet the required form factor of the optical cochlear implant. We facilitate the upscaling of optical stimulation channels by combining custom-designed and complementary elements with lateral channel pitches of only 100 micrometers throughout the optical pathway. Our biomedical engineering focusses on achieving efficacy and safety by housing all electronic components in a hermetically sealed titanium housing with optical feedthroughs and efficient and stable light in- and outcoupling of the waveguide array. The optical cochlear implant has the potential to revolutionize hearing restoration, merging scientific innovation with clinical impact, and transforming lives globally.